Antifungal activity of essential oils in natura and ozonized on the etiological agent of sporotrichosis
DOI:
https://doi.org/10.6008/CBPC2179-6858.2021.003.0012Keywords:
Sporothrix schenckii, Ozone, Medicinal plantsAbstract
Sporotrichosis is a ringworm caused by species of Sporothrix schenckii. The treatment of this disease is carried out using conventional antifungals. The emergence of resistant strains has led to alternative treatments, such as natural medicines or the use of ozone gas. The aim of this research was to evaluate the antifungal activity of fresh and ozonated essential oils against Sporothrix schenckii. Fresh and ozonated essential oils of Cinnamomum cassia, Syzygium aromaticum, Cymbopogon winterianus, Eucalyptus globulus, Eucalyptus staigeriana and Mentha piperita were used, evaluated for antifungal activity against the standard strain of Sprothrix schenckii ATCC 16345. The oils were ozonated in corona equipment. The microdilution technique was used to assess the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC). The fungicidal kinetics of essential oils were determined. The data obtained were evaluated by the Mann-Whitney test and the Kruskal-Wallis test. The natural and ozonated essential oils of cinnamon, cloves, citronella, eucalyptus and mint showed antifungal activity against Sporothrix schenckii. Ozonized clove oil was more effective in reducing the fungal load, requiring 20 minutes to completely eliminate the fungal structures. Evidencing the possibility of use in S. schenckii antifungal therapy.
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